The SCIENCE
by A Mind For All Seasons®
“The important thing is to never stop questioning.”
-Albert Einstein
Your questions are most welcome!
When people have questions, we get excited! We started asking our own questions early on and haven’t stopped! The power behind The Enhance Protocol, the ability to prevent and, in some cases, reverse dementia; all of that comes because what we do is founded on sound science; Science we found because we were willing to keep asking questions! To our fellow questioners, we offer our repository of science that we lean on as a public resource! It’s been proven that the more feedback you get on an idea, the better the idea becomes. We welcome your insights, questions about, and improvements on our methods and science! We’re on a mission to change lives one brain at a time, and we welcome every ally to our cause!
General Overview of The Enhance Protocol
We offer an integrative model that is new to the neurological worlds. Because it is a fresh approach, it has yet to produce mounds of clinical research. That is partly because the traditional allopathic/pharmaceutical model has historically studied one variable at a time (usually a drug). If the study variable separates itself from the placebo group with statistical significance, it holds promise. However, what do you do with multiple variables, multiple triggers of cognitive decline?
Many chronic diseases like Alzheimer’s, heart disease, and type 2 diabetes are affected by multiple factors that are unlikely to be effectively prevented or treated with a single therapy. Currently, internal review boards that authorize clinical trials are less inclined to study multiple interventions at a time, which is why there are few large-scale trials of multi-modal approaches. That being said, consider the following:
Reversal of Cognitive Decline: 100 patients
Reversal of Cognitive Decline: 100 patients was a collaborative publication with many physicians across the country who occupy this space of multivariate intervention for Alzheimer’s Dementia. Dale Bredesen was the principal investigator: https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450.pdf.
We have worked with hundreds of clients in the last four years and have consistently seen results equal to or surpassing what Dr. Bredesen and his colleagues outline in this paper.
Reversal of Cognitive Decline
Reversal of Cognitive Decline was a Bredesen pilot publication that outlined the need to customize the interventions for each individual metabolic profile, genetics, age, disease process, etc. Though a pilot trial, reading through the case histories help providers recognize the need to identify the root causes of each individual disease process and intervene accordingly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931830/
The Finger Trial
The Finger Trial was an early publication linking metabolic risk factors and multivariate intervention for the prevention of cognitive decline: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60461-5/fulltext
US Pointer Study
Since this trial was conducted in Finland, the US Pointer Study is currently underway in the US to validate the results. Though the trial has not yet been completed, it provides a framework for guiding CCM/coaching to those at highest risk for dementia now. Because there is cross over between risk factors for dementia and CVD, DM, IR and a host of other chronic diseases, when you modify the risk factors for dementia the cross-over disease challenges often improve: https://clinicaltrials.gov/ct2/show/NCT03688126
Alzheimers Disease and Prevention Clinic at Cornell
Richard Isaacson, MD is a neurologist that runs the Alzheimers Disease and Prevention Clinic at Cornell. He has spoken extensively about the importance and value of early interventions for those with SCI, MCI and AD. You can read about his work here: https://weillcornell.org/services/neurology/alzheimers-disease-memory-disorders-program/our-services/alzheimers-prevention-clinic
Additional Considerations & Resources
When we consider all the single-variable trials that have been conducted but failed to prove statistically significant in the treatment or reduction of AD, we suggest much more ‘statistical significance’ would be noted if we combined all variables together, such as lifestyle interventions (diet, exercise, sleep, stress management, smoking, alcohol use, socialization), existing disease burden reduction (HTN, CVD risk reduction, DM & metabolic risk reduction, blood glucose, insulin, A1c, Trig:HDL ratios), early and responsible hormone optimization (Estradiol, Testosterone, Progesterone, Pregnenolone DHEA), nutritional support (vitamin B1, B6, B12, folic acid, vitamin C, omegas, antioxidants, magnesium, zinc, copper), methylation support, reduction in inflammatory markers, and on and on. This approach is discussed in this summary printed in the Lancet.
There are many other physicians and integrative medical practitioners that have embraced the perspective. Like autism, Alzheimers and other forms of dementia are spectrum disorder(s). Most authors below are NYT bestselling authors who blog extensively that when clinical practice combines the best that allopathic medicine has to offer with lifestyle coaching, risk reduction and integrative medicine, many individuals note improvements and reduce the financial and caregiver burden of dementia. These authors include, but are not limited to
- Dr.’s Sherzai, Neurologists from Loma Linda, California- https://teamsherzai.com/
- Dr. Gayatri Devi from New York- https://www.amazon.com/Spectrum-Hope-Optimistic-Alzheimers-Dementias/dp/076119309X
- Dr. Perlmutter, Neurologist https://www.drperlmutter.com/grain-brain-revised-edition/
- Dr. Bredesen- Neurologist from UCLA- https://www.apollohealthco.com/book/the-end-of-alzheimers/
- Dr. Daniel Amen form the Amen Clinics- https://brainmd.com/cd-bright-minds-memory-rescue-music
- Dr. Mark Hyman from the Cleveland Clinic – https://drhyman.com/blog/2010/08/30/the-ultramind-solution-the-6-week-plan-to-heal-your-brain-2/
- Dr. Richard Isaacson from Weill-Cornell at NYU- https://www.alzu.org/
More Coming Soon.. Lots More!
Cataloging, organizing, and uploading our entire vault of science is something that takes time! We have SO MUCH MORE science that we are still working on getting added here to our Science page! These resources will be up here soon, but in the meantime, feel free to call us and talk science!
The Science
Broken Link? Newer Science? Let us know!
New research is coming out constantly, and because external sites and studies may occasionally update their sites and change their link structure, we may have a broken link we don’t know about! If you know of new research or spot a broken link, you can let us know via the contact form on this page (click here), and we’ll update it ASAP!
